Resources

Publications

Find Pacira-sponsored publications specific to EXPAREL, ZILRETTA, and iovera°.

A phase 3 active-controlled trial of liposomal bupivacaine via sciatic nerve block in the popliteal fossa after bunionectomy.

Schwartz G, Gadsden JC, Gonzales J, et al. J Clin Anesth. 2024;94:111402. DOI: 10.1016/j.jclinane.2024.111402.
View Publication
Simulated bupivacaine pharmacokinetics after labor epidural analgesia followed by transversus abdominis plane block with liposomal bupivacaine for intrapartum cesarean delivery.

Katz D, Song J, Carangelo M, Bergsma T, Winston R, Landau R. J Clin Anesth. 2024 Dec;99:111589. doi: 10.1016/j.jclinane.2024.111589. Epub 2024 Sep 21. PMID: 39307067.
View Publication
Liposomal bupivacaine via adductor canal block after total knee arthroplasty: a randomized, double-blind, phase 3 trial.

Gadsden J, Hamilton M, Schwartz G, et al. Poster presented at: 48th Annual Regional Anesthesiology and Acute Pain Medicine Meeting; April 20, 2023; Hollywood, FL. Poster 4381.
A multicenter study to evaluate the pharmacokinetics and safety of liposomal bupivacaine for postsurgical analgesia in pediatric patients aged 6 to less than 17 years (PLAY).

Tirotta CF, de Armendi AJ, Horn ND, et al. J Clin Anesth. 2021;75:110503.
View Publication
Liposomal Bupivacaine Infiltration After Median Sternotomy in Pediatric Cardiac Surgery.

Tirotta CF, Lagueruela RG, Salyakina D, Gupta A, Alonso F, Inoa J, Hughes J, Pappas J, Burke R. J Cardiothorac Vasc Anesth. 2021 Jun;35(6):1715-1721. doi: 10.1053/j.jvca.2021.01.053. Epub 2021 Feb 6. PMID: 33663978.
View Publication
Brachial plexus block with liposomal bupivacaine for shoulder surgery improves analgesia and reduces opioid consumption: results from a multicenter, randomized, double-blind, controlled trial.

Patel MA, Gadsden JC, Nedeljkovic SS, et al. Pain Med. 2020;21(2):387-400.
View Publication
Transversus abdominis plane block with liposomal bupivacaine for pain after cesarean delivery in a multicenter, randomized, double-blind, controlled trial.

Nedeljkovic SS, Kett A, Vallejo MC, et al. Anesth Analg. 2020;131(6):1830-1839.
View Publication
Bupivacaine pharmacokinetics and breast milk excretion of liposomal bupivacaine administered after cesarean birth.

Mustafa HJ, Wong HL, Al‐Kofahi M, Schaefer M, Karanam A, Todd MM. Obstet Gynecol. 2020;136(1):70‐76.
View Publication
Local infiltration analgesia with liposomal bupivacaine improves pain scores and reduces opioid use after total knee arthroplasty: results of a randomized controlled trial.

Mont MA, Beaver WB, Dysart SH, Barrington JW, Del Gaizo DJ. J Arthroplasty. 2018;33(1):90-96.
View Publication
Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies.

Baxter R, Bramlett K, Onel E, Daniels S. Clin Ther. 2013;35(3):312-320.
View Publication
Pharmacokinetic profile of liposome bupivacaine injection following a single administration at the surgical site.

Hu D, Onel E, Singla N, Kramer WG, Hadzic A. Clin Drug Invest. 2013;33(2):109-115.
View Publication
A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty.

Bramlett K, Onel E, Viscusi ER, Jones K. Knee. 2012;19(5):530-536.
View Publication
Bupivacaine extended release liposome injection for prolonged postsurgical analgesia in patients undergoing hemorrhoidectomy: a multicenter, randomized, double-blind, placebo-controlled trial.

Gorfine SR, Onel E, Patou G, Krivokapic ZV. Dis Colon Rectum. 2011;54(12):1552-1559.
View Publication
A phase 3, randomized, placebo-controlled trial of DepoFoam^® bupivacaine (extended-release bupivacaine local analgesic) in bunionectomy.

Golf M, Daniels SE, Onel E. Adv Ther. 2011 Sep;28(9):776-88. doi:10.1007/s12325-011-0052-y. Epub 2011 Aug 12. PMID: 21842428.
View Publication

Validation of a Novel Landmark-guided Intra-articular Postero-medial Surgeon-administered Injection Technique.

Piuzzi NS, Spitzer AI, Mussell J, Pasqualini I, Dysart S, Gonzales J, Mont MA, Lonner JH, Mihalko W. Arthroplast Today. 2025 Jan 25;31:101619. doi: 10.1016/j.artd.2025.101619. PMID: 39927121; PMCID: PMC11803215.
View Publication

Enhanced Recovery After Surgery (ERAS)

Enhanced Recovery After Surgery (ERAS) Pathways

Enhanced Recovery After Surgery (ERAS) pathways are evidence-based multidisciplinary programs utilizing standardized multimodal perioperative care to achieve early recovery in patients undergoing surgery and improve patient outcomes. One key focus of ERAS includes the use of multimodal, opioid-sparing approaches for pain management. Organizations such as ERAS, Procedure-specific Postoperative Pain Management (PROSPECT) group, and American Society for Enhanced Recovery (ASER) provide guidelines on procedure-specific ERAS pathways for postoperative recovery and pain management.¹

ERAS is designed to:

Attenuate patient stress²
Maintain preoperative bodily compositions and organ function²
Integrate throughout the perioperative pathway³
Maintain physiologic function²
Facilitate (early) postoperative recovery²
Reduce complications and length of stay³
Increase value by reducing and improving quality of care^2,3

References

Cheung CK, Adeola JO, Beutler SS, Urman RD. Postoperative Pain Management in Enhanced Recovery Pathways. J Pain Res. 2022;15:123-135.
Miller TE, Gan TJ, Thacker JK. Enhanced Recovery Pathways for Major Abdominal Surgery. Anesth News. 2014:1-8.
Miller TE, Thacker JK, White WD, et al. Reduced Length of Hospital Stay in Colorectal Surgery after Implementation of an Enhanced Recovery Protocol. Anesth Analg. 2014;118(5):1052-1061.

VIEW MATERIALS

Clinical Trial Information

Pacira is committed to delivering innovative, non-opioid pain therapies to transform the lives of patients and provide relief to patients suffering from pain. Ongoing research and clinical trials are helping to expand access for patients to non-opioid pain management. Learn more about Pacira-sponsored clinical trials, including active and completed trials, and discover how you can become more involved.

Learn More about Pacira-sponsored clinical trials

Investigator Initiated Trials (IITs) and Grants

Pacira remains committed to providing non-opioid pain management and regenerative health solutions dedicated to advancing and improving outcomes for health care practitioners and their patients. To that end, Pacira provides grants for IITs, independent educational grants, and grants in support of medical missions/charitable donations.

Learn More About Pacira Grants and Corporate Giving

Pacira supports IITs by parties interested in pursuing research in our therapeutic areas of interest. These research trials provide valued information on the safety, efficacy, pharmacology, and tolerability of the company’s marketed products.

Learn More About Investigator-Initiated Trials

Read, download, and interact with a library of resources on non-opioid pain management, Pacira’s portfolio, and more.

Publications

EXPAREL® (bupivacaine liposome injectable suspension)

ZILRETTA® (triamcinolone acetonide extended-release injectable suspension)

iovera°®

IGOR (Innovations in Genicular Outcomes Registry)

IPSA (Intra-articular Postero-medial Surgeon-administered Injection Technique)

Health Economics Outcomes Research

Enhanced Recovery After Surgery (ERAS)

Enhanced Recovery After Surgery (ERAS) Pathways

Enhanced Recovery After Surgery (ERAS) Pathways

References

Clinical Trial Information

Investigator Initiated Trials (IITs) and Grants

Investigator Initiated Trials (IITs) and Grants